An inhibitor of LIMK1 and LIMK2
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BMS-3

Item No. 19421

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-cyclopropanecarboxamide
CAS Number
1338247-30-5
Molecular Formula
C17H12Cl2F2N4OS
Formula Weight
429.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 25mg/mlDMSO:PBS (pH 7.2)(1:5): 0.2 mg/mlEthanol: 1 mg/ml
λmax
299 nm
SMILES
O=C(C1CC1)NC2=NC=C(C3=CC(C(F)F)=NN3C4=C(Cl)C=CC=C4Cl)S2
InChi Code
InChI=1S/C17H12Cl2F2N4OS/c18-9-2-1-3-10(19)14(9)25-12(6-11(24-25)15(20)21)13-7-22-17(27-13)23-16(26)8-4-5-8/h1-3,6-8,15H,4-5H2,(H,22,23,26)
InChi Key
YBGGBHCJSAEIAS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $236

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    25 mg

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    Product Description

    BMS-3 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 (IC50s = 5 and 6 nM, respectively).1 It is used to study the role of activated LIMK isoforms in the signaling of Rho family GTPases to cytoskeletal proteins, including cofilin and tubulin.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ross-Macdonald, P., de Silva, H., Guo, Q., et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol. Cancer Ther. 7(11), 3490-3498 (2008).

    2. Li, X., Zhu, Y., Cao, Y., et al. LIM kinase activity is required for microtubule organising centre positioning in mouse oocyte meiosis. Reprod. Fertil. Dev. 29(4), 791-804 (2016).

    3. Romarowski, A., Battistone, M.A., La Spina, F.A., et al. PKA-dependent phosphorylation of LIMK1 and Cofilin is essential for mouse sperm acrosomal exocytosis. Dev. Biol. 405(2), 237-249 (2015).

    4. Sari-Hassoun, M., Clement, M.-J., Hamdi, I., et al. Cucurbitacin I elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-kinase. Biochem. Pharmacol. 102, 45-63 (2016).