An inhibitor of TNF-α-induced HIV replication
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O-Methylviridicatin

Item No. 19446

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methoxy-4-phenyl-2(1H)-quinolinone
CAS Number
6152-57-4
Synonyms
  • AIDS-089094
  • 3-methoxy-4-phenyl-Carbostyril
  • Viridicatin methyl ester
Molecular Formula
C16H13NO2
Formula Weight
251.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
O=C1NC2=C(C=CC=C2)C(C3=CC=CC=C3)=C1OC
InChi Code
InChI=1S/C16H13NO2/c1-19-15-14(11-7-3-2-4-8-11)12-9-5-6-10-13(12)17-16(15)18/h2-10H,1H3,(H,17,18)
InChi Key
NDTLHHOQSHJIMX-UHFFFAOYSA-N
Origin
Bacterium/Penicillium sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $180

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    5 mg

    $669

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    Cayman Chemical
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    Product Description

    O-Methylviridicatin is a natural derivative of the alkaloid mycotoxin viridicatin, which is produced by several species of Penicillium.1 O-Methylviridicatin blocks activation of the HIV long terminal repeat by TNF-α in HeLa cells (IC50 = 5 µM).2 It also inhibits virus production in OM-10.1 cells (HL-60 promyelocytes infected with HIV-1) treated with TNF-α (IC50 = 2.5 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Santini, A., Mikusová, P., Sulyok, M., et al. Penicillium strains isolated from Slovak grape berries taxonomy assessment by secondary metabolite profile. Mycotoxin Res. 30(4), 213-220 (2014).

    2. Heguy, A., Cai, P., Meyn, P., et al. Isolation and characterization of the fungal metabolite 3-O-methylviridicatin as an inhibitor of tumour necrosis factor α-induced human immunodeficiency virus replication. Antivir. Chem. Chemoth. 9(2), 149-155 (1998).