An AMPK activator
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YLF-466D

Item No. 19475

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[(3E)-3-[(4-chlorophenyl)phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-1-yl]methyl]-benzoic acid
CAS Number
1273323-67-3
Molecular Formula
C29H20ClNO3
Formula Weight
465.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 10 mg/ml
λmax
341 nm
SMILES
O=C1N(CC2=CC=CC(C(O)=O)=C2)C3=C(C=CC=C3)/C1=C(C4=CC=CC=C4)\C5=CC=C(Cl)C=C5
InChi Code
InChI=1S/C29H20ClNO3/c30-23-15-13-21(14-16-23)26(20-8-2-1-3-9-20)27-24-11-4-5-12-25(24)31(28(27)32)18-19-7-6-10-22(17-19)29(33)34/h1-17H,18H2,(H,33,34)/b27-26+
InChi Key
BPBOVHROVFJFAH-CYYJNZCTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    YLF-466D is an orally bioavailable activator of AMP-activated protein kinase (AMPK), an enzyme involved in regulation of cellular energy homeostasis.1 YLF-466D activates AMPK at a concentration of 150 µM in platelets. It inhibits platelet aggregation induced by thrombin, ADP, and collagen (IC50s = 84, 55, and 87 µM, respectively) and inhibits aggregation of whole blood. YLF-466D leads to dose-dependent glucose uptake in L6 myotubes and, at a dose of 150 mg/kg, improves glucose tolerance in two mouse models of diabetes.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, Y., Park, J.-M., Oh, S.-J., et al. Antiplatelet effect of a newly developed AMP-activated protein kinase activator YLF-466D. Eur. J. Pharmacol. 760, 81-87 (2015).

    2. Yu, L.-F., Lo, Y.-Y., Su, M.-B., et al. Development of novel alkene oxindole derivatives as orally efficacious AMP-activated protein kinase activators. ACS Med. Chem. Lett. 4(5), 475-480 (2013).

    3. Li, Y.-Y., Yu, L.-F., Zhang, L.-N., et al. Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice. Toxicol. Appl. Pharmacol. 273(2), 325-334 (2013).