An agonist of RORγt
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SR 0987

Item No. 19503

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzamide
CAS Number
303126-97-8
Molecular Formula
C16H10ClF6NO2
Formula Weight
397.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 15 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 30 mg/ml
λmax
255 nm
SMILES
ClC1=CC=CC=C1C(NC2=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C2)=O
InChi Code
InChI=1S/C16H10ClF6NO2/c17-12-4-2-1-3-11(12)13(25)24-10-7-5-9(6-8-10)14(26,15(18,19)20)16(21,22)23/h1-8,26H,(H,24,25)
InChi Key
IZVBONMVWLTLNT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    SR 0987 is an agonist of the T cell-specific isoform of RORγ (RORγt, retinoic acid receptor-related orphan receptor-γt), inducing reporter gene expression with an EC50 value of ~800 nM.1 Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA (Item No. 10008014) and ionomycin (Item No. 10004974), increases expression of the RORγt target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged.1 Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chang, M.R., Dharmarajan, V., Doebelin, C., et al. Synthetic RORγt Agonists Enhance Protective Immunity. ACS Chem. Biol. 11(4), 1012-1018 (2016).