A selective inhibitor of PI3Kα
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INK1117

Item No. 19514

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[6-(2-amino-5-benzoxazolyl)imidazo[1,2-a]pyridin-3-yl]-4-morpholinyl-methanone
CAS Number
1268454-23-4
Synonyms
  • MLN1117
  • TAK-117
Molecular Formula
C19H17N5O3
Formula Weight
363.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.25 mg/mLDMSO: 1 mg/mLDMSO:PBS (pH 7.2) (1:10): 0.09 mg/mL
λmax
234, 298 nm
SMILES
NC1=NC2=CC(C(C=C3)=CN4C3=NC=C4C(N5CCOCC5)=O)=CC=C2O1
InChi Code
InChI=1S/C19H17N5O3/c20-19-22-14-9-12(1-3-16(14)27-19)13-2-4-17-21-10-15(24(17)11-13)18(25)23-5-7-26-8-6-23/h1-4,9-11H,5-8H2,(H2,20,22)
InChi Key
BLGWHBSBBJNKJO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    25 mg

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    Product Description

    INK1117 is an inhibitor of phosphoinositide 3-kinase α (PI3Kα) that is selective for p110α in vitro (IC50 = 15 nM for PI3Kα vs. >1 µM for other isoforms, as well as for mTOR) and in cells when used at 1 µM.1,2 It blocks signaling to Akt and inhibits growth of cancer cells harboring wild-type or mutated p110α.1 INK1117 does not interfere with B cell proliferation or NK cell maturation and survival.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. So, L., Yea, S.S., Oak, J.S., et al. Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte function. The Journal of Biological Chemisty 288(8), 5718-5731 (2013).

    2. Yea, S.S., So, L., Mallya, S., et al. Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function. PLoS One 9(6), (2014).