A major metabolite of histamine
Related Products
Labeled Version(s)
437971-Methylhistamine-d3 (hydrochloride)
Parent Compound(s)
33828Histamine
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1-Methylhistamine (hydrochloride)

Item No. 19516

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-H-imidazole-4-ethanamine, dihydrochloride
CAS Number
6481-48-7
Synonyms
  • N1-Methylhistamine
  • Ntau-Methylhistamine
  • tele-Methylhistamine
Molecular Formula
C6H11N3 • 2HCl
Formula Weight
198.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
217 nm
SMILES
CN1C=NC(CCN)=C1.Cl.Cl
InChi Code
InChI=1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H
InChi Key
AGXVEALMQHTMSW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $134

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    25 mg

    $280

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    50 mg

    $488

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    100 mg

    $834

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    Product Description

    1-Methylhistamine is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism.1 It has been used as a biomarker of brain histaminergic system activity via cerebrospinal fluid (CSF) levels in Alzheimer’s disease patients, as well as those with hypersomnia or other neurological conditions.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lindell, S.E., and Schayer, R.W. Metabolism of injected [14C] histamine in the kidney of the dog. Br. J. Pharmacol. Chemother. 13(1), 52-53 (1958).

    2. Motawaj, M., Peoc'h, K., Callebert, J., et al. CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer’s disease. J. Alzheimers Dis. 22(3), 861-871 (2010).

    3. Dauvilliers, Y., Delallée, N., Jaussent, I., et al. Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions. Sleep 35(10), 1359-1366 (2016).