Blocks Tie2 kinase activity
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Tie2 Inhibitor 7

Item No. 19535

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[4-[[[2-[[(1S)-1-cyclohexylethyl]amino]-2-oxoethyl][(4-methylphenoxy)carbonyl]amino]methyl]phenyl]-3-pyridinecarboxylic acid
CAS Number
1020412-97-8
Molecular Formula
C31H35N3O5
Formula Weight
529.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2)(1:9): 0.1 mg/mlEthanol: 1 mg/ml
λmax
257 nm
SMILES
CC1=CC=C(C=C1)OC(N(CC(N[C@H](C2CCCCC2)C)=O)CC3=CC=C(C=C3)C4=CC(C(O)=O)=CN=C4)=O
InChi Code
InChI=1S/C31H35N3O5/c1-21-8-14-28(15-9-21)39-31(38)34(20-29(35)33-22(2)24-6-4-3-5-7-24)19-23-10-12-25(13-11-23)26-16-27(30(36)37)18-32-17-26/h8-18,22,24H,3-7,19-20H2,1-2H3,(H,33,35)(H,36,37)/t22-/m0/s1
InChi Key
GHHDFOFSMBLLDX-QFIPXVFZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $134

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    1 mg

    $253

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    Product Description

    Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 µM.1. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 µM.1 This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, J., Lin, T.H., Cole, A.G., et al. Identification and characterization of small-molecule inhibitors of Tie2 kinase. FEBS Lett. 582(5), 785-791 (2008).