A CCR2 antagonist
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CCR2 Antagonist

Item No. 19542

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
rel-2-[[[(1-methylethyl)amino]carbonyl]amino]-N-[2-[[(1R,2S)-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)-benzamide
CAS Number
445479-97-0
Synonyms
  • BMS CCR2-22
Molecular Formula
C28H34F3N5O4S
Formula Weight
593.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
CSC1=CC=C(C(N[C@@H]2CCCC[C@@H]2NC(CNC(C3=CC(C(F)(F)F)=CC=C3NC(NC(C)C)=O)=O)=O)=O)C=C1
InChi Code
InChI=1S/C28H34F3N5O4S/c1-16(2)33-27(40)36-21-13-10-18(28(29,30)31)14-20(21)26(39)32-15-24(37)34-22-6-4-5-7-23(22)35-25(38)17-8-11-19(41-3)12-9-17/h8-14,16,22-23H,4-7,15H2,1-3H3,(H,32,39)(H,34,37)(H,35,38)(H2,33,36,40)/t22-,23+/m0/s1
InChi Key
IBPXYDUJQWENPM-XZOQPEGZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    CCR2 antagonist is an antagonist of chemokine (C-C motif) receptor 2 (CCR2).1 It binds to CCR2 in a radioligand binding assay using peripheral blood mononuclear cells (PBMCs; IC50 = 5.1 nM). CCR2 antagonist inhibits chemotaxis induced by chemokine (C-C motif) ligand 2 (CCL2) in PBMCs (IC50 = 1 nM). In vivo, CCR2 antagonist (2 mg/kg) reduces hepatic Ly6C+ monocyte recruitment and viral clearance in mice infected with hepatitis B virus (HBV).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cherney, R.J., Mo, R., Meyer, D.T., et al. Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists. J. Med. Chem. 51(4), 721-724 (2008).

    2. Wu, L.L., Peng, W.H., Wu, H.L., et al. Lymphocyte antigen 6 complex, locus C+ monocytes and Kupffer cells orchestrate liver immune responses against hepatitis B virus in mice. Hepatology 69(6), 2364-2380 (2019).