Ferulenol

Ferulenol is a prenylated 4-hydroxycoumarin first isolated from F. communis that demonstrates potent antimycobacterial activity.¹ It does not directly affect blood coagulation but at concentrations less than 100 nM has been shown to impair factor X biosynthesis.² Ferulenol has also been shown to stimulate tubulin polymerization in vitro, rearranging cellular microtubule networks into short fibers and altering nuclear morphology, which leads to cytotoxicity in various human tumor cell lines.³ Ferulenol is reported to disrupt oxidative phosphorylation, inhibiting succinate ubiquinone reductase without altering succinate dehydrogenase activity of complex II of the electron chain transport system.⁴

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1. Mamoci, E., Cavoski, I., Simone, V., et al. Chemical composition and in vitro activity of plant extracts from Ferula communis and Dittrichia viscosa against postharvest fungi. Molecules 16(3), 2609-2625 (2011).

2. Monti, M., Pinotti, M., Appendino, G., et al. Characterization of anti-coagulant properties of prenylated coumarin ferulenol. Biochim. Biophys. Acta 1770(10), 1437-1440 (2007).

3. Bocca, C., Gabriel, L., Bozzo, F., et al. Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol. Planta Med. 68(12), 1135-1137 (2002).

4. Lahouel, M., Zini, R., Zellagui, A., et al. Ferulenol specifically inhibits succinate ubiquinone reductase at the level of the ubiquinone cycle. Biochem. Biophys. Res. Commun. 355(1), 252-257 (2007).