Umbelliprenin

Umbelliprenin is a prenylated coumarin that has been found in Ferula and has diverse biological activities.^1,2 It inhibits 5-lipoxygenase (5-LO) in a cell-free assay (IC₅₀ = 72.5 nM).¹ Umbelliprenin is active against L. major promastigotes (IC₅₀ = 13.3 µM). It induces cell cycle arrest at the G₁ phase in, as well as inhibits the growth of (IC₅₀ = 12.5 µM), M4Beu metastatic pigmented melanoma cells and reduces tumor volume in a mouse Lewis lung carcinoma model. It reduces tumor growth and the number of metastases in a 4T1 mouse allograft model.² Umbelliprenin (0.01 mmol/kg) reduces carrageenan-induced paw edema in mice.¹

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1. Shakeri, A., Iranshahy, M., and Iranshahi, M. Biological properties and molecular targets of umbelliprenin--a mini-review. J. Asian Nat. Prod. Res. 16(8), 884-889 (2014).

2. Rashidi, M., Khalilnezhad, A., Amani, D., et al. Umbelliprenin shows antitumor, antiangiogenesis, antimetastatic, anti-inflammatory, and immunostimulatory activities in 4T1 tumor-bearing Balb/c mice. J. Cell. Physiol. 233(11), 8908-8918 (2018).