A selective activator of p300 HAT
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CTPB

Item No. 19570

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-6-pentadecyl-benzamide
CAS Number
586976-24-1
Molecular Formula
C31H43ClF3NO2
Formula Weight
554.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH7.2) (1:2): 0.33 mg/mlDMSO: 20 mg/mlEthanol: 15 mg/ml
λmax
258 nm
SMILES
ClC1=CC=C(NC(C2=C(CCCCCCCCCCCCCCC)C=CC=C2OCC)=O)C=C1C(F)(F)F
InChi Code
InChI=1S/C31H43ClF3NO2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-18-24-19-17-20-28(38-4-2)29(24)30(37)36-25-21-22-27(32)26(23-25)31(33,34)35/h17,19-23H,3-16,18H2,1-2H3,(H,36,37)
InChi Key
OYBMVMAXKOGYDC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    Product Description

    CTPB is an amide derivative that selectively activates the histone acetyltransferase (HAT) p300, with maximal activation at 275 µM.1 It directly binds p300.2 CTPB does not alter PCAF HAT or histone deacetylase activity.1 It dose-dependently increases the acetylation of histones H3 and H4, with maximal effect at 200 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Balasubramanyam, K., Swaminathan, V., Ranganathan, A., et al. Small molecule modulators of histone acetyltransferase p300. The Journal of Biological Chemisty 278(21), 19134-19140 (2003).

    2. Devipriya, B., Parameswari, A.R., Rajalakshmi, G., et al. Exploring the binding affinities of p300 enzyme activators CTPB and CTB using docking method. Indian J. Biochem. Biophys. 47(6), 364-369 (2010).