A selective PP2A inhibitor
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Rubratoxin A

Item No. 19605

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S,5R,10R)-rel-10-[(R)-[(2R)-3,6-dihydro-6-oxo-2H-pyran-2-yl]hydroxymethyl]-4,5,8,9,10,11-hexahydro-4,8-dihydroxy-5-[(1S)-1-hydroxyheptyl]-1H-cyclonona[1,2-c:5,6-c']difuran-1,3,6-trione
CAS Number
22467-31-8
Synonyms
  • BRN 1633008
  • HSDB 3532
Molecular Formula
C26H32O11
Formula Weight
520.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleDMSO: soluble
SMILES
O=C1C2=C(C[C@@]([C@H](O)[C@]3([H])CC=CC(O3)=O)([H])CC(C(OC4=O)=O)=C4[C@H](O)[C@]2([H])[C@H](O)CCCCCC)C(O)O1
InChi Code
InChI=1S/C26H32O11/c1-2-3-4-5-7-15(27)20-18-13(23(31)36-25(18)33)10-12(21(29)16-8-6-9-17(28)35-16)11-14-19(22(20)30)26(34)37-24(14)32/h6,9,12,15-16,20-23,27,29-31H,2-5,7-8,10-11H2,1H3/t12-,15+,16-,20+,21-,22-,23?/m0/s1
InChi Key
XOEFANNJIKAWGX-RRIJHKHGSA-N
Origin
Fungus/Penicillium sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Rubratoxin A is a natural mycotoxin and competitive inhibitor of protein phosphatase 2A (PP2A; IC50 = 170 nM).1 It has no significant effect on several other phosphatases, including PP1, PP2B, and protein tyrosine phosphatase 1B. Rubratoxin A drives overphosphorylation of PP2A substrate proteins in cultured cells treated for three hours at 20 µM.1 It causes suppression of tumor metastasis and reduction of primary tumor volume in mouse xenografts.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wada, S.i., Usami, I., Umezawa, Y., et al. Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis. Cancer Sci. 101(3), 743-750 (2010).