An hTAS2R31 and hTAS2R43 antagonist
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Product Type

Small Molecule Modulators
Receptor Pharmacology
Antagonists

Research Area

4-(2,2,3-Trimethylcyclopentyl)butanoic Acid

Item No. 19606

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2,3-trimethyl-cyclopentanebutanoic acid
CAS Number
957136-80-0
Synonyms
  • GIV3727
Molecular Formula
C12H22O2
Formula Weight
198.3
Purity
≥98%
Formulation
A 10 mg/ml solution in methanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 0.25 mg/ml
SMILES
OC(CCCC1CCC(C)C1(C)C)=O
InChi Code
InChI=1S/C12H22O2/c1-9-7-8-10(12(9,2)3)5-4-6-11(13)14/h9-10H,4-8H2,1-3H3,(H,13,14)
InChi Key
LYFXCRCUENNESS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $108

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    10 mg

    $172

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    50 mg

    $429

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    Product Description

    4-(2,2,3-Trimethylcyclopentyl)butanoic acid is an orthosteric, insurmountable antagonist of the human bitter taste receptors hTAS2R31 and hTAS2R43.1 It prevents the activation of hTAS2R31 by saccharin and acesulfame K in cells with IC50 values of 7.9 and 2.4 µM, respectively.1 In human sensory trials, 4-(2,2,3-trimethylcyclopentyl)butanoic acid significantly reduced the bitter flavor associated with these two artificial sweeteners.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Slack, J.P., Brockhoff, A., Batram, C., et al. Modulation of bitter taste perception by a small molecule hTAS2R antagonist. Curr. Biol. 20(12), 1104-1109 (2010).