An inhibitor of microtubule assembly
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Curvulin

Item No. 19609

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-acetyl-3,5-dihydroxy-benzeneacetic acid, ethyl ester
CAS Number
19054-27-4
Molecular Formula
C12H14O5
Formula Weight
238.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetone: SolubleDMSO: SolubleMethanol: Soluble
SMILES
OC1=CC(CC(OCC)=O)=C(C(C)=O)C(O)=C1
InChi Code
InChI=1S/C12H14O5/c1-3-17-11(16)5-8-4-9(14)6-10(15)12(8)7(2)13/h4,6,14-15H,3,5H2,1-2H3
InChi Key
TURXCFUGBPBPRS-UHFFFAOYSA-N
Origin
Fungus/Curvularia sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $169

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    5 mg

    $502

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    Cayman Chemical
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    Product Description

    Curvulin is a phytotoxin first isolated from several species of the mold Curvularia. It is reported to inhibit microtubule assembly and has also been shown to inhibit iNOS expression.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tadross, P.M., Virgil, S.C., and Stoltz, B.M. Aryne acyl-alkylation in the general and convergent synthesis of benzannulated macrolactone natural products: an enantioselective synthesis of (−)-curvularin. Org. Lett. 12(7), 1612-1614 (2010).

    2. Yao, Y., Hausding, M., Erkel, G., et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol. Pharmacol. 63(2), 383-391 (2003).