A PPARγ agonist
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Amorfrutin B

Item No. 19618

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-2-hydroxy-4-methoxy-6-(2-phenylethyl)-benzoic acid
CAS Number
78916-42-4
Molecular Formula
C26H32O4
Formula Weight
408.5
Purity
≥97%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
SMILES
OC(C(C(O)=C(C/C=C(C)/CC/C=C(C)/C)C(OC)=C1)=C1CCC2=CC=CC=C2)=O
InChi Code
InChI=1S/C26H32O4/c1-18(2)9-8-10-19(3)13-16-22-23(30-4)17-21(24(25(22)27)26(28)29)15-14-20-11-6-5-7-12-20/h5-7,9,11-13,17,27H,8,10,14-16H2,1-4H3,(H,28,29)/b19-13+
InChi Key
DKNIJLWIVUCTHW-CPNJWEJPSA-N
Origin
Plant/Amorpha fruticosa
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $163

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    1 mg

    $278

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Amorfrutin B is a partial agonist of the peroxisome proliferator-activated receptor γ (PPARγ; Ki = 19 nM and EC50 = 73 nM) that was first isolated from A. fruticosa.1 It binds to PPARα and PPARβ/δ with Ki values of 2.6 and 1.7 µM, respectively.1 In insulin-resistant mice, 100 mg/kg/day amorfrutin B is reported to improve insulin sensitivity, glucose tolerance, and plasma lipid concentrations after two weeks of treatment.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Weidner, C., Wowro, S.J., Freiwald, A., et al. Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPARγ) agonist with potent glucose-lowering properties. Diabetologia 56(8), 1802-1812 (2013).