A selective β3-adrenergic receptor antagonist
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L-748,337

Item No. 19643

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[3-[(2S)-2-hydroxy-3-[[2-[4-[(phenylsulfonyl)amino]phenyl]ethyl]amino]propoxy]phenyl]methyl]-acetamide
CAS Number
244192-94-7
Molecular Formula
C26H31N3O5S
Formula Weight
497.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
SMILES
CC(NCC1=CC=CC(OC[C@@H](O)CNCCC2=CC=C(NS(C3=CC=CC=C3)(=O)=O)C=C2)=C1)=O
InChi Code
InChI=1S/C26H31N3O5S/c1-20(30)28-17-22-6-5-7-25(16-22)34-19-24(31)18-27-15-14-21-10-12-23(13-11-21)29-35(32,33)26-8-3-2-4-9-26/h2-13,16,24,27,29,31H,14-15,17-19H2,1H3,(H,28,30)/t24-/m0/s1
InChi Key
AWIONHVPTYTSHZ-DEOSSOPVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $235

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    25 mg

    $487

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    Product Description

    L-748,337 is a β3-adrenergic receptor antagonist that displays selectivity over β1 and β2 receptors (Kis = 4, 390, and 204 nM, respectively).1 It has been shown to couple with Gi to activate MAPK signaling.2 L-748,337 can inhibit agonist-stimulated lipolysis in rhesus monkey adipocytes, as well as agonist-induced relaxation of smooth muscle.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Candelmore, M.R., Deng, L., Tota, L., et al. Potent and selective human β3-adrenergic receptor antagonists. J. Pharmacol. Exp. Ther. 290(2), 649-655 (1999).

    2. Sato, M., Hutchinson, D.S., Evans, B.A., et al. The β3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human β3-adrenoceptor. Mol. Pharmacol. 74(5), 1417-1428 (2008).