A natural α1-adrenoceptor antagonist
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Racanisodamine

Item No. 19650

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-(hydroxymethyl)-benzeneacetic acid, 6-hydroxy-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
CAS Number
17659-49-3
Synonyms
  • 6-hydroxy Hyoscyamine
Molecular Formula
C17H23NO4
Formula Weight
305.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
O=C(C(CO)C1=CC=CC=C1)OC2CC(N3C)C(O)CC3C2
InChi Code
InChI=1S/C17H23NO4/c1-18-12-7-13(9-15(18)16(20)8-12)22-17(21)14(10-19)11-5-3-2-4-6-11/h2-6,12-16,19-20H,7-10H2,1H3
InChi Key
WTQYWNWRJNXDEG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 mg

    $41

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    250 mg

    $80

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    500 mg

    $99

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    1 g

    $157

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    Product Description

    Racanisodamine is a natural tropane alkaloid shown to be a weak antagonist of α1-adrenoceptors, blocking WB-4101 and clonidine (Item No. 15949) binding in brain membrane preparations with pKi values of 2.63 and 1.61, respectively.1 Racanisodamine also has antioxidant effects that may protect against free radical-induced cellular damage.2 Racanisodamine is predominantly found in the roots of A. tanguticus, which is used in traditional Chinese medicine for topical applications.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Varma, D.R., and Yue, T.L. Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of rats. Br. J. Pharmacol. 87(3), 587-594 (1986).

    2. Poupko, J.M., Baskin, S.I., and Moore, E. The pharmacological properties of anisodamine. J. Appl. Toxicol. 27(2), 116-121 (2007).

    3. Ma, L., Gu, R., Tang, L., et al. Important poisonous plants in Tibetan ethnomedicine. Toxins (Basel) 7(1), 138-155 (2015).