A selective adensosine A2A receptor antagonist
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SCH 58261

Item No. 19676

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2-furanyl)-7-(2-phenylethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
CAS Number
160098-96-4
Molecular Formula
C18H15N7O
Formula Weight
345.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2) (1:2): 0.33 mg/mlDMSO: 10 mg/ml
λmax
232, 262 nm
SMILES
NC(N1C2=NC(C3=CC=CO3)=N1)=NC4=C2C=NN4CCC5=CC=CC=C5
InChi Code
InChI=1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)
InChi Key
UTLPKQYUXOEJIL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $117

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    10 mg

    $196

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    25 mg

    $420

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    Product Description

    SCH 58261 is a competitive antagonist of the adenosine A2A receptor (Kis = 2.3 and 2.0 nM in rat and bovine brain, respectively).1 It is selective for the A2A subtype, displaying an A1/A2A selectivity ratio of 50-100-fold and does not interact with A2B or A3 receptors.1 SCH 58261 has been used to improve 6-hydroxy dopamine-induced motor deficits in a rat model of Parkinson’s disease.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zocchi, C., Ongini, E., Ferrara, S., et al. Binding of the radioligand [3H]-SCH 58261, a new non-xanthine A2A adenosine receptor antagonist, to rat striatal membranes. Br. J. Pharmacol. 117(7), 1381-1386 (1996).

    2. Reyhani-Rad, S., and Mahmoudi, J. Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat. Acta Cir. Bras. 31(2), 133-137 (2016).