An anthelmintic
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Labeled Version(s)
27842Fenbendazole-d3
Metabolite(s)
20921Fenbendazole sulfone
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Fenbendazole

Item No. 19687

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[6-(phenylthio)-1H-benzimidazol-2-yl]-carbamic acid, methyl ester
CAS Number
43210-67-9
Synonyms
  • Methyl 5-(phenylthio)-2-benzimidazolecarbamate
Molecular Formula
C15H13N3O2S
Formula Weight
299.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mLDMSO: 10 mg/mL
λmax
218, 296 nm
SMILES
O=C(OC)NC1=NC2=CC(SC3=CC=CC=C3)=CC=C2N1
InChi Code
InChI=1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)
InChi Key
HDDSHPAODJUKPD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

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    Cayman Chemical
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    Product Description

    Fenbendazole is a benzimidazole anthelmintic.1 It is active against Giardia in vitro (IC50 = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection.2 Fenbendazole also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Morgan, U.M., Reynoldson, J.A., and Thompson, R.C.A. Activities of several benzimidazoles and tubulin inhibitors against Giardia spp. in vitro. Antimicrob. Agents Chemother. 37(2), 328-331 (1993).

    2. Suter, C., Müller-Doblies, U.U., Hatt, J.-M., et al. Prevention and treatment of Encephalitozoon cuniculi infection in rabbits with fenbendazole. Vet. Rec. 148(15), 478-480 (2001).

    3. Aleyasin, H., Karuppagounder, S.S., Kumar, A., et al. Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin. Antioxid. Redox Signal. 22(2), 121-134 (2015).