An internal standard for the quantification of fenbendazole
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Unlabeled Version(s)
19687Fenbendazole
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Fenbendazole-d3

Item No. 27842

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
methyl-d3 (5-(phenylthio)-1H-benzo[d]imidazol-2-yl)carbamate
CAS Number
1228182-47-5
Synonyms
  • Methyl 5-(phenylthio)-2-benzimidazolecarbamate-d3
Molecular Formula
C15H10D3N3O2S
Formula Weight
302.4
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
O=C(OC([2H])([2H])[2H])NC1=NC2=CC(SC3=CC=CC=C3)=CC=C2N1
InChi Code
InChI=1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)/i1D3
InChi Key
HDDSHPAODJUKPD-FIBGUPNXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Fenbendazole-d3 is intended for use as an internal standard for the quantification of fenbendazole (Item No. 19687) by GC- or LC-MS. Fenbendazole is a benzimidazole anthelmintic.1 It is active against Giardia in vitro (IC50 = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection.2 It also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Morgan, U.M., Reynoldson, J.A., and Thompson, R.C.A. Activities of several benzimidazoles and tubulin inhibitors against Giardia spp. in vitro. Antimicrob. Agents Chemother. 37(2), 328-331 (1993).

    2. Suter, C., Müller-Doblies, U.U., Hatt, J.-M., et al. Prevention and treatment of Encephalitozoon cuniculi infection in rabbits with fenbendazole. Vet. Rec. 148(15), 478-480 (2001).

    3. Aleyasin, H., Karuppagounder, S.S., Kumar, A., et al. Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin. Antioxid. Redox Signal. 22(2), 121-134 (2015).