A cell-permeable p38 MAP kinase inhibitor
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(S)-p38 MAPK Inhibitor III

Item No. 19696

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-2-pyridinamine
CAS Number
581098-48-8
Synonyms
  • (S)-p38 MAP Kinase Inhibitor III
  • (S)-p38 Mitogen-activated Protein Kinase Inhibitor III
Molecular Formula
C23H21FN4S
Formula Weight
404.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 12 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.33 mg/ml
λmax
253, 304 nm
SMILES
FC1=CC=C(C2=C(C3=CC=NC(N[C@@H](C)C4=CC=CC=C4)=C3)N=C(SC)N2)C=C1
InChi Code
InChI=1S/C23H21FN4S/c1-15(16-6-4-3-5-7-16)26-20-14-18(12-13-25-20)22-21(27-23(28-22)29-2)17-8-10-19(24)11-9-17/h3-15H,1-2H3,(H,25,26)(H,27,28)/t15-/m0/s1
InChi Key
VXPWQNBKEIVYIS-HNNXBMFYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 µg

    $75

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    1 mg

    $143

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    5 mg

    $589

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    10 mg

    $1,030

    Add
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    Product Description

    (S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 µM in vitro).1 It is cell-permeable, potently blocking the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC50s = 0.37 and 0.044 µM, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Laufer, S.A., Wagner, G.K., Kotschenreuther, D.A., et al. Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J. Med. Chem. 46(15), 3230-3244 (2003).