A Certified Reference Material
Features
  • This product is qualified as a Certified Reference Material (CRM) that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This CRM has been characterized by metrologically valid procedures and may be used as a quantitative analytical reference standard
  • Certificate of analysis provides the certified property values and the associated uncertainties, including a statement of metrological traceability for the certified values
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Desalkylflurazepam (CRM)

A 1 mg/ml solution in methanol

Item No. 19698

Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • N-Desalkylflurazepam
  • N-Desalkyl-2-oxoquazepam
  • nor-Flurazepam
  • Norfludiazepam
  • Ro 5-3367
Technical Information
Formal Name
7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
CAS Number
2886-65-9
Molecular Formula
C15H10ClFN2O
Formula Weight
288.7
Formulation
A 1 mg/ml solution in methanol
SMILES
ClC(C=C1)=CC2=C1NC(CN=C2C3=CC=CC=C3F)=O
InChi Code
InChI=1S/C15H10ClFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)
InChi Key
UVCOILFBWYKHHB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    Product Description

    Desalkylflurazepam (CRM) (Item No.19698) is an analytical reference material that is structurally categorized as a benzodiazepine. It is an active metabolite of several benzodiazepines, including flurazepam (Item No. 18160), flutoprazepam, fludiazepam, midazolam (Item Nos. 19391 | 16193), and quazepam. Desalkylflurazepam inhibits L-type voltage-gated calcium channels (Cav; IC50s = 55 and 37 µM for Cav1.2 and 1.3, respectively) by positively modulating GABAA receptors.1 It can be detected in urine, serum, and meconium by LC-MS/MS.2 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Earl, D.E., and Tietz, E.I. Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors. J. Pharmacol. Exp. Ther. 337(1), 301-311 (2011).

    2. Marin, S.J., Coles, R., Merrell, M., et al. Quantitation of benzodiazepines in urine, serum, plasma, and meconium by LC-MS-MS. J. Anal. Toxicol. 32(7), 491-498 (2008).