A selective antagonist of the purinergic P2Y6 receptor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Small Molecule Modulators
Receptor Pharmacology
Antagonists

Research Area

MRS2578

Item No. 19704

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N''-1,4-butanediylbis[N'-(3-isothiocyanatophenyl)-thiourea
CAS Number
711019-86-2
Molecular Formula
C20H20N6S4
Formula Weight
472.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 10 mg/ml
λmax
217, 273 nm
SMILES
S=C(NCCCCNC(NC1=CC=CC(N=C=S)=C1)=S)NC2=CC(N=C=S)=CC=C2
InChi Code
InChI=1S/C20H20N6S4/c27-13-23-15-5-3-7-17(11-15)25-19(29)21-9-1-2-10-22-20(30)26-18-8-4-6-16(12-18)24-14-28/h3-8,11-12H,1-2,9-10H2,(H2,21,25,29)(H2,22,26,30)
InChi Key
QOHNRGHTJPFMSL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $49

    Add

    10 mg

    $86

    Add

    25 mg

    $202

    Add

    50 mg

    $354

    Add
    Product Description

    MRS2578 is an antagonist of the purinergic P2Y6 receptor (IC50s = 37 and 98 nM for human and rat receptors, respectively).1 It is without effect at other purinergic receptors. MRS2578 is used to study the cellular and physiological roles of P2Y6.2,3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mamedova, L.K., Joshi, B.V., Gao, Z.-G., et al. Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem. Pharmacol. 67(9), 1763-1770 (2004).

    2. Koizumi, S., Shigemoto-Mogami, Y., Nasu-Tada, K., et al. UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature 446(78139), 1091-1095 (2007).

    3. Kukulski, F., Ben Yebdri, F., Lefebvre, J., et al. Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo. J. Leukoc. Biol. 81(5), 1269-1275 (2007).

    4. Ma, X., Pan, X., Wei, Y., et al. Chemotherapy-induced uridine diphosphate release promotes breast cancer metastasis through P2Y6 activation. Oncotarget 7(20), 29036-29050 (2016).

    5. Sil, P., Hayes, C.P., Reaves, B.J., et al. P2Y6 receptor antagonist MRS2578 inhibits neutrophil activation and aggregated neutrophil extracellular trap formation induced by gout-associated monosodium urate crystals. J. Immunol. 198(1), 428-442 (2017).