An anthocyanidin with diverse biological activities
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Pelargonidin (chloride)

Item No. 19753

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5,7-trihydroxy-2-(4-hydroxyphenyl)-1-benzopyrylium, monochloride
CAS Number
134-04-3
Molecular Formula
C15H11O5 • Cl
Formula Weight
306.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlEthanol: 1 mg/ml
λmax
269, 426, 524 nm
SMILES
OC1=CC(O)=C(C=C(O)C(C2=CC=C(O)C=C2)=[O+]3)C3=C1.[Cl-]
InChi Code
InChI=1S/C15H10O5.ClH/c16-9-3-1-8(2-4-9)15-13(19)7-11-12(18)5-10(17)6-14(11)20-15;/h1-7H,(H3-,16,17,18,19);1H
InChi Key
YPVZJXMTXCOTJN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $178

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    50 mg

    $775

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    Product Description

    Pelargonidin is an anthocyanidin that has been found in P. granatum and has diverse biological activities.1,2,3,4 It scavenges superoxide anions in cell-free assays (IC50 = 130 µg/ml) and inhibits hydrogen peroxide-induced lipid peroxidation in rat brain homogenates (IC50 = 85 µM).1 Pelargonidin (3 mg/kg) reduces serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), hepatocyte apoptosis, and hepatic levels of IL-1β, IL-6, TNF-α, and TGF-β in a mouse model of hepatotoxicity induced by acetaminophen (Item No. 10024).2 It increases survival and reduces pulmonary fibrosis and leukocyte infiltration in a mouse model of LPS-induced endotoxemia.3 Pelargonidin (0.04-0.4 mg/kg) reduces serum levels of nitric oxide (NO), TNF-α, and IL-6 and increases renal myeloperoxidase (MPO), superoxide dismutase (SOD), and catalase (CAT) activities, as well as increases survival, in a mouse model of cecal ligation and puncture-induced sepsis.4 It also decreases escape latency in the Morris water maze, reduces hippocampal malondialdehyde (MDA) levels, and increases hippocampal acetylcholinesterase (AChE) activity in a rat model of Alzheimer's disease induced by amyloid-β 25-35 (Aβ (25-35); Item No. 24155).5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Noda, Y., Kaneyuki, T., Mori, A., et al. Antioxidant activities of pomegranate fruit extract and its anthocyanidins: Delphinidin, cyanidin, and pelargonidin. J. Agric. Food Chem. 50(1), 166-171 (2002).

    2. Seo, M., Kim, H., Lee, J.H., et al. Pelargonidin ameliorates acetaminophen-induced hepatotoxicity in mice by inhibiting the ROS-induced inflammatory apoptotic response. Biochimie 168, 10-16 (2020).

    3. Lee, B.-S., Lee, C., Yang, S., et al. Suppressive effects of pelargonidin on lipopolysaccharide-induced inflammatory responses. Chem. Biol. Interact. 302, 67-73 (2019).

    4. Lee, I.-C., and Bae, J.-S. Pelargonidin protects against renal injury in a mouse model of sepsis. J. Med. Food 22(1), 57-61 (2019).

    5. Sohanaki, H., Baluchnejadmojarad, T., Nikbakht, F., et al. Pelargonidin improves memory deficit in amyloid β25-35 rat model of Alzheimer’s disease by inhibition of glial activation, cholinesterase, and oxidative stress. Biomed. Pharmacother. 83, 85-91 (2016).