Jaceosidin

Jaceosidin is a natural methylated trihydroxyflavone first isolated from plants of the Compositae family. Like many flavones, jaceosidin has antioxidative actions on cells in culture.¹ It induces cell cycle arrest and apoptosis in cancer cells, suggesting potential roles in cancer therapy.^2,3,4 Jaceosidin also blocks cell signaling related to inflammation, including activation of NF-κB and induced expression of cyclooxygenase 1, inducible nitric oxide synthase, and matrix metalloproteinase-9.^1,5

WARNING This product is not for human or veterinary use.

1. Kim, M.-J., Han, J.-M., Jin, Y.-Y., et al. In vitro antioxidant and anti-inflammatory activities of Jaceosidin from Artemisia princeps Pampanini cv. Sajabal. Arch. Pharm. Res. 31(4), 42-437 (2008).

2. Lee, J.-G., Kim, J.-H., Ahn, J.-H., et al. Jaceosidin, isolated from dietary mugwort (Artemisia princeps), induces G₂/M cell cycle arrest by inactivating cdc25C-cdc2 via ATM-Chk1/2 activation. Food Chem. Toxicol. 55, 214-221 (2013).

3. Lv, W., Sheng, X., Chen, T., et al. Jaceosidin induces apoptosis in human ovary cancer cells through mitochondrial pathway. J. Biomed. Biotechnol. 394802 (2008).

4. Woo, S.M., and Kwon, T.K. Jaceosidin induces apoptosis through Bax activation and down-regulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells. Chem. Biol. Interact. 260, 168-175 (2016).

5. Jeong, M.A., Lee, K.W., Yoon, D.-Y., et al. Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells. Ann. N. Y. Acad. Sci. 1095, 458-466 (2007).