A flavone with diverse biological activities
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Tricin

Item No. 35835

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-1-benzopyran-4-one
CAS Number
520-32-1
Synonyms
  • NSC 294579
  • 4’,5,7-Trihydroxy-3’,5’-dimethoxyflavone
Molecular Formula
C17H14O7
Formula Weight
330.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 10 mg/ml
λmax
246, 271, 354 nm
SMILES
O=C1C=C(C2=CC(OC)=C(O)C(OC)=C2)OC3=C1C(O)=CC(O)=C3
InChi Code
InChI=1S/C17H14O7/c1-22-14-3-8(4-15(23-2)17(14)21)12-7-11(20)16-10(19)5-9(18)6-13(16)24-12/h3-7,18-19,21H,1-2H3
InChi Key
HRGUSFBJBOKSML-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $51

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    5 mg

    $179

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    10 mg

    $253

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    25 mg

    $505

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    Cayman Chemical
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    Product Description

    Tricin is a flavone that has been found in O. sativa and has diverse biological activities.1,2,3,4 It scavenges ABTS (Item No. 27317) radicals in a cell-free assay (IC50 = 0.312 mg/ml).1 Tricin (0.1-10 µM) reduces virus titer and expression of the human cytomegalovirus (HCMV) genes IE1 and UL54 in HCMV-infected human embryonic lung fibroblast (HEL) cells, an effect that can be reversed by overexpression of chemokine (C-C motif) ligand 2 (CCL2).2 It inhibits IgE-induced degranulation of RBL-2H3 cells (IC50 = 4.83 µM).3 In vivo, tricin (37.5 mg/kg per day) reduces tumor growth and the number of lung metastases in a CT26 murine colon carcinoma model.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Quan, N.V., Thien, D.D., Khanh, T.D., et al. Momilactones A, B, and tricin in rice grain and by-products are potential skin aging inhibitors. Foods 8(12), 602 (2019).

    2. Akai, Y., Sadanari, H., Takemoto, M., et al. Inhibition of human cytomegalovirus replication by tricin is associated with depressed CCL2 expression. Antiviral Res. 148, 15-19 (2017).

    3. Kuwabara, H., Mouri, K., Otsuka, H., et al. Tricin from a malagasy connaraceous plant with potent antihistaminic activity. J. Nat. Prod. 66(9), 1273-1275 (2003).

    4. Yue, G.G.-L., Gao, S., Lee, J.K.-M., et al. A natural flavone tricin from grains can alleviate tumor growth and lung metastasis in colorectal tumor mice. Molecules 25(16), 3730 (2020).