Paeonol

Paeonol is a phenol that has been found in Paeonia and has diverse biological activities.^1,2,3,4 It inhibits LPS- and IFN-γ-induced migration and production of reactive oxygen species (ROS) in BV-2 microglia when used at concentrations of 10 and 30 µM.¹ Paeonol inhibits histamine release from rat peritoneal mast cells induced by compound 48/80 (Item No. 22173) and reduces mortality in a mouse model of compound 48/80-induced anaphylactic shock when administered at a dose of 0.5 mg per animal.² It reduces hepatic necrosis and serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in a mouse model of hepatotoxicity induced by acetaminophen (Item No. 10024) when administered at a dose of 100 mg/kg.³ Paeonol (30, 50, and 100 mg/kg) inhibits carrageenan-induced thermal hyperalgesia and production of nitric oxide (NO) and prostaglandin E₂ (PGE₂; Item No. 14010) in rats.⁴

WARNING This product is not for human or veterinary use.

1. Lin.C., Lin, H.-Y., Chen, J.-H., et al. Effects of paeonol on anti-neuroinflammatory responses in microglial cells. Int. J. Mol. Sci. 16(4), 8844-8860 (2015).

2. Kim, S.H., Kim, S.-A., Park, M.-K., et al. Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-ɑ. Int. Immunopharmacol. 4(2), 279-287 (2004).

3. Ding, Y., Li, Q., Xu, Y., et al. Attenuating oxidative stress by paeonol protected against acetaminophen-induced hepatotoxicity in mice. PloS One 11(5), (2016).

4. Chou, T.-C. Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia. Br. J. Pharmacol. 139(6), 1146-1152 (2003).