A mast cell degranulator
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Compound 48/80 (hydrochloride)

Item No. 22173

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Molecular Formula
C32H45N3O3 • XHCl (for trimer)
Formula Weight
519.7
Purity
≥95% (mixture of polymers)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: 100 mM
λmax
278 nm
SMILES
COC1=C(C)C=C(CCNC)C=C1CC.Cl
InChi Code
InChI=1S/C13H21NO.ClH/c1-5-12-9-11(6-7-14-3)8-10(2)13(12)15-4;/h8-9,14H,5-7H2,1-4H3;1H
InChi Key
ZEJPKHRIWWFMTH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 mg

    $145

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Compound 48/80 is a condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde that causes histamine degranulation from mast cells.1 Compound 48/80 also inhibits human platelet aggregation through suppression of calmodulin (CaM) (IC50 = 0.41 μg/ml for CaM-dependent Ca2+-transporter ATPase activity) and phospholipase C (IC50s = 2.1 and 5.0 μg/ml for cytosolic and particulate phosphatidylinositol-specific activities, respectively).2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rothschild, A.M. Mechanisms of histamine release by compound 48/80. Br. J. Pharmac. 38(1), 253-262 (1970).

    2. Adamczyk-Engelmann, P., and Gietzen, K. Induction of histamine release and calmodulin antagonism are two distinct properties of compound 48/80. Cell Calcium 10(2), 93-99 (1989).

    3. Bronner, C., Charles, W., Didier, M., et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim. Biophys. Acta 920(3), 301-305 (1987).