A chalcone and flavonoid with diverse biological activities
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Isomer(s)
34673Bavachalcone 11843Glabridin
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Isobavachalcone

Item No. 19873

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-1-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
CAS Number
20784-50-3
Synonyms
  • Corylifolinin
  • IBC
Molecular Formula
C20H20O4
Formula Weight
324.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 30 mg/mLEthanol: 30 mg/mLEthanol:PBS (pH 7.2) (1:4): 0.2 mg/mL
λmax
369 nm
SMILES
OC1=CC=C(/C=C/C(C2=C(O)C(C/C=C(C)/C)=C(O)C=C2)=O)C=C1
InChi Code
InChI=1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3/b11-6+
InChi Key
DUWPGRAKHMEPCM-IZZDOVSWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $158

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    25 mg

    $370

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    50 mg

    $653

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    Product Description

    Isobavachalcone (IBC) is a chalcone and flavonoid originally isolated from P. corylifolia and has diverse biological activities.1,2 It is active against C. albicans and C. neoformans (IC50s = 3 and 7 µg/ml, respectively), as well as T. rubrum and M. audouinii (MIC = 1.2 µg/ml for both).1 IBC is active against various Bacillus, Streptococcus, and Proteus species, as well as K. pneumoniae, P. aeruginosa, S. typhi, M. morganii, E. aerogenes, C. freundii, and E. cloacae (MICs = 4.9-39.1 µg/ml). It induces mitochondrial-mediated apoptosis in IMR-32 and NB-39 human neuroblastoma cells and inhibits the proliferation of OVCAR-8 ovarian, PC3 prostate, MCF-7 breast, and A549 lung cancer cell lines. IBC (50 mg/kg) reduces dopaminergic neuronal cell death and increases the stay time in the rotarod test in a mouse model of MPTP-induced Parkinson’s disease.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kuete, V., and Sandjo, L.P. Isobavachalcone: An overview. Chin. J. Integr. Med. 18(7), 543-547 (2012).

    2. Jing, H., Wang, S., Wang, M., et al. Isobavachalcone attenuates MPTP-induced Parkinson’s disease in mice by inhibition of microglial activation through NF-κB pathway. PLoS One 12(1), e0169560 (2017).