A natural isoflavonoid with diverse actions
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Isomer(s)
19873Isobavachalcone
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Glabridin

Item No. 11843

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(3R)-3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]-3-benzenediol
CAS Number
59870-68-7
Molecular Formula
C20H20O4
Formula Weight
324.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:6): 0.14 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
λmax
228, 281 nm
SMILES
OC(C=C1)=CC(O)=C1[C@H]2CC3=CC=C4OC(C)(C)C=CC4=C3OC2
InChi Code
InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1
InChi Key
LBQIJVLKGVZRIW-ZDUSSCGKSA-N
Origin
Plant/Glycyrrhiza glabra
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $98

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    25 mg

    $130

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    50 mg

    $186

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    Cayman Chemical
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    Product Description

    Glabridin is a prenylated isoflavonoid found in licorice root extract that is reported to possess antiviral, antimicrobial, anti-inflammatory, antidiabetic, antiatherogenic, antioxidant, antitumor, and estrogen-like properties.1,2,3 These diverse biological activities are largely related to the capacity of glabridin to down-regulate reactive oxygen species, bind to antioxidant effectors, and act as a selective estrogen receptor modulator.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, L., Yang, R., Yuan, B., et al. The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb. Acta Pharm. Sin. B 5(4), 310-315 (2015).

    2. Ming, L.J., and Yin, A.C. Therapeutic effects of glycyrrhizic acid. Nat. Prod. Commun. 8(3), 415-418 (2013).

    3. Lee, K.J., Oh, Y.C., Cho, W.K., et al. Antioxidant and anti-inflammatory activity determination of one hundred kinds of pure chemical compounds using offline and online screening HPLC assay. Evid. Based Complement. Alternat. Med. 165457 (2015).

    4. Simmler, C., Pauli, G.F., and Chen, S.-N. Phytochemistry and biological properties of glabridin. Fitoterapia 90, 160-184 (2013).