A BTK inhibitor
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Acalabrutinib

Item No. 19899

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-benzamide
CAS Number
1420477-60-6
Synonyms
  • ACP-196
Molecular Formula
C26H23N7O2
Formula Weight
465.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 15 mg/ml
λmax
229, 283, 336 nm
SMILES
O=C(NC1=CC=CC=N1)C(C=C2)=CC=C2C3=C(C(N)=NC=C4)N4C([C@@H]5CCCN5C(C#CC)=O)=N3
InChi Code
InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1
InChi Key
WDENQIQQYWYTPO-IBGZPJMESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $110

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    10 mg

    $169

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    25 mg

    $294

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    Product Description

    Acalabrutinib is an irreversible inhibitor of Bruton’s tyrosine kinase (BTK). It can dose-dependently inhibit B cell receptor signaling in primary chronic lymphocytic leukemia cells.1 In kinase-inhibition assays, acalabrutinib was more selective than ibrutinib (Item No. 16274) for inhibiting BTK and did not inhibit EGFR, Itk, or Txk signaling.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Burd, J.C., Harrington, B., O'Brien, S., et al. Acalabrutinib (ACP-196) in relapsed chronic lymphocytic leukemia. N. Engl. J. Med. 374(4), 323-332 (2016).