AP-III-a4 (CAS 1177827-73-4) | Cayman Chemical
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AP-III-a4

Item № 19933
CAS № 1177827-73-4
Purity ≥95%
product image
                (CAS 1177827-73-4)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $55.00 0.00
     5 mg $248.00 0.00
     10 mg $440.00 0.00
     25 mg $825.00 0.00

Pricing updated 2019-01-16. Prices are subject to change without notice.

Description
Synonyms
  • ENOblock

AP-III-a4 is a small molecule enolase inhibitor (IC50 = 0.576 µM) that inhibited cancer cell metastasis in an in vivo zebrafish cancer cell xenograft model.1 It also reduced hyperglycemia and hyperlipidemia in C57BL/Ksj-db/db mice, a transgenic model of type 2 diabetes.2 Another study found that AP-III-a4 did not directly block enolase activity in vitro and suggested the mechanism is indirect.3

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Technical Information
Formal Name
N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-[[4-[(cyclohexylmethyl)amino]-6-[[(4-fluorophenyl)methyl]amino]-1,3,5-triazin-2-yl]amino]-benzeneacetamide
CAS Number
1177827-73-4
Synonyms
  • ENOblock
Molecular Formula
C31H43FN8O3
Formula Weight
594.7
Purity
≥95%
Formulation
A crystalline solid
λmax
211, 268 nm
SMILES
FC(C=C1)=CC=C1CNC2=NC(NC3=CC=C(CC(NCCOCCOCCN)=O)C=C3)=NC(NCC4CCCCC4)=N2
InChI Code
InChI=1S/C31H43FN8O3/c32-26-10-6-25(7-11-26)22-36-30-38-29(35-21-24-4-2-1-3-5-24)39-31(40-30)37-27-12-8-23(9-13-27)20-28(41)34-15-17-43-19-18-42-16-14-33/h6-13,24H,1-5,14-22,33H2,(H,34,41)(H3,35,36,37,38,39,40)
InChI Key
MOVYITHKOHMLHC-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Jung, D.-W., Kim, W.-H., Park, S.-H., et al. A unique small molecule inhibitor of enolase clarifies its role in fundamental biological processes ACS Chem Biol. 8(6), 1271-1282 (2013).

2. Cho, H., Um, J., Lee, J.-H., et al. ENOblock, a unique small molecule inhibitor of the non-glycolytic functions of enolase, alleviates the symptoms of type 2 diabetes Sci. Rep. 7, 44186 (2017).

3. Satani, N., Lin, Y.-H., Hammoudi, N., et al. ENOblock does not inhibit the activity of the glycolytic enzyme enolase PLoS One 11(12), e0168739 (2016).

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