A small molecule enolase inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

AP-III-a4

Item No. 19933

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-[[4-[(cyclohexylmethyl)amino]-6-[[(4-fluorophenyl)methyl]amino]-1,3,5-triazin-2-yl]amino]-benzeneacetamide
CAS Number
1177827-73-4
Synonyms
  • ENOblock
Molecular Formula
C31H43FN8O3
Formula Weight
594.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
λmax
211, 268 nm
SMILES
FC(C=C1)=CC=C1CNC2=NC(NC3=CC=C(CC(NCCOCCOCCN)=O)C=C3)=NC(NCC4CCCCC4)=N2
InChi Code
InChI=1S/C31H43FN8O3/c32-26-10-6-25(7-11-26)22-36-30-38-29(35-21-24-4-2-1-3-5-24)39-31(40-30)37-27-12-8-23(9-13-27)20-28(41)34-15-17-43-19-18-42-16-14-33/h6-13,24H,1-5,14-22,33H2,(H,34,41)(H3,35,36,37,38,39,40)
InChi Key
MOVYITHKOHMLHC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $79

    Add

    5 mg

    $345

    Add

    10 mg

    $649

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    AP-III-a4 is a small molecule enolase inhibitor (IC50 = 0.576 µM) that inhibited cancer cell metastasis in an in vivo zebrafish cancer cell xenograft model.1 It also reduced hyperglycemia and hyperlipidemia in C57BL/Ksj-db/db mice, a transgenic model of type 2 diabetes.2 Another study found that AP-III-a4 did not directly block enolase activity in vitro and suggested the mechanism is indirect.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jung, D.-W., Kim, W.-H., Park, S.-H., et al. A unique small molecule inhibitor of enolase clarifies its role in fundamental biological processes. ACS Chem Biol. 8(6), 1271-1282 (2013).

    2. Cho, H., Um, J., Lee, J.-H., et al. ENOblock, a unique small molecule inhibitor of the non-glycolytic functions of enolase, alleviates the symptoms of type 2 diabetes. Sci. Rep. 7, 44186 (2017).

    3. Satani, N., Lin, Y.-H., Hammoudi, N., et al. ENOblock does not inhibit the activity of the glycolytic enzyme enolase. PLoS One 11(12), e0168739 (2016).