An anticancer antibiotic
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Aureothricin

Item No. 19942

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-propanamide
CAS Number
574-95-8
Synonyms
  • Farcinicin
  • Propionylpyrrothione
Molecular Formula
C9H10N2O2S2
Formula Weight
242.3
Purity
≥98%
Formulation (Request formulation change)
A powder
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: partially solubleMethanol: partially soluble
SMILES
CN1C2=CSSC2=C(NC(CC)=O)C1=O
InChi Code
InChI=1S/C9H10N2O2S2/c1-3-6(12)10-7-8-5(4-14-15-8)11(2)9(7)13/h4H,3H2,1-2H3,(H,10,12)
InChi Key
UGZYFXMSMFMTSM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $156

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    1 mg

    $263

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    5 mg

    $846

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    Cayman Chemical
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    Product Description

    Aureothricin is a dithiolopyrrolone antibiotic first isolated from Streptomyces sp. that exhibits broad-spectrum antimicrobial activity against many Gram-positive and Gram-negative bacteria, as well as strains of M. tuberculosis.1 It is also reported to inhibit tumor angiogenesis, blocking activity of the vitronectin receptor integrin αvβ3 with an IC50 value of 1.1 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, B., Wever, W.J., Walsh, C.T., et al. Dithiolopyrrolones: Biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics. Nat. Prod. Rep. 31(7), 905-923 (2014).

    2. Minamiguchi, K., Kumagai, H., Masuda, T., et al. Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Int. J. Cancer 93(3), 307-316 (2001).