A UV-activated DNA crosslinking probe
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Product Type

Biochemicals
Labeling & Detection
Reactive Probes
Natural Products

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Trioxsalen

Item No. 20044

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,5,9-trimethyl-7H-furo[3,2-g][1]benzopyran-7-one
CAS Number
3902-71-4
Synonyms
  • NSC 71047
  • 4,5’,8-Trimethylpsoralen
  • Trisoralen
Molecular Formula
C14H12O3
Formula Weight
228.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Dichloromethane: Soluble
λmax
250, 291, 335 nm
SMILES
CC1=CC2=CC(C(C)=C3)=C(C(C)=C2O1)OC3=O
InChi Code
InChI=1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3
InChi Key
FMHHVULEAZTJMA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $41

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    100 mg

    $75

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    250 mg

    $178

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    500 mg

    $255

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    Product Description

    Trioxsalen is a derivative of the photoactive probe psoralen (Item No. 11751). Like psoralen, trioxsalen intercalates into DNA and forms DNA single-strand adducts and interstrand crosslinks when activated with ultraviolet light.1,2 It is used to study DNA structure as well as the cellular response to DNA damage. Trioxsalen and other psoralens photosensitize skin cells to ultraviolet light.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McNeill, D.R., Paramaslvam, M., Baldwin, J., et al. NEIL1 responds and binds to psoralen-induced DNA interstrand crosslinks. The Journal of Biological Chemisty 288(18), 12426-12436 (2013).

    2. Iyama, T., Lee, S.Y., Berquist, B.R., et al. CSB interacts with SNM1A and promotes DNA interstrand crosslink processing. Nucleic Acids Res. 43(1), 247-258 (2015).

    3. Pathak, M.A., Marciani, M.S., Guiotto, A., et al. A study of the relationship between photosensitizing and therapeutic activity of 4,5',8-trimethylpsoralen, and its major metabolite 4,8-dimethyl, 5'-carboxypsoralen. J. Invest. Dermatol. 81(6), 533-539 (1983).