An inhibitor of HGFR (c-Met)
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INCB 28060

Item No. 20056

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-benzamide
CAS Number
1029712-80-8
Synonyms
  • Capmatinib
  • INC 280
Molecular Formula
C23H17FN6O
Formula Weight
412.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 0.30 mg/ml
λmax
228, 252, 303, 316, 383 nm
SMILES
CNC(C1=CC=C(C2=NN3C(N=C2)=NC=C3CC4=CC=C(N=CC=C5)C5=C4)C=C1F)=O
InChi Code
InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
InChi Key
LIOLIMKSCNQPLV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    INCB 28060 is an inhibitor of heptatocyte growth factor receptor (HGFR, also known as c-Met), potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activity in cells (IC50 values range from 0.3 to 1.1 nM).1 It blocks cell proliferation and migration or induces apoptosis in different types of cancer cells.1 INCB 28060 is orally bioavailable and inhibits the growth of HGFR-dependent tumors in mice.1 It also improves efficacy of gemcitabine (Item No. 11690) in a mouse pancreatic cancer model and reduces migration and adhesion in ovarian cancer cell models.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, X., Wang, Q., Yang, G., et al. A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3. Clin. Cancer. Res 17(22), 127-138 (2011).

    2. Brandes, F., Schmidt, K., Wagner, C., et al. Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model. BMC Cancer 15:71, (2015).

    3. Moran-Jones, K., Brown, L.M., and Samimi, G. INC280, an orally available small molecule inhibitor of c-MET, reduces migration and adhesion in ovarian cancer cell models. Sci. Rep. 5:11749, (2015).