An activator of soluble guanylate cyclase
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BAY 60-2770

Item No. 20077

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(4-carboxybutyl)[2-[5-fluoro-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]methoxy]phenyl]ethyl]amino]methyl]-benzoic acid
CAS Number
1027642-43-8
Molecular Formula
C35H33F4NO5
Formula Weight
623.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
FC(C=C1)=CC(CCN(CCCCC(O)=O)CC2=CC=C(C(O)=O)C=C2)=C1OCC(C=C3)=CC=C3C4=CC=C(C(F)(F)F)C=C4
InChi Code
InChI=1S/C35H33F4NO5/c36-31-16-17-32(45-23-25-6-8-26(9-7-25)27-12-14-30(15-13-27)35(37,38)39)29(21-31)18-20-40(19-2-1-3-33(41)42)22-24-4-10-28(11-5-24)34(43)44/h4-17,21H,1-3,18-20,22-23H2,(H,41,42)(H,43,44)
InChi Key
CRQMDXFUKDWARU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    BAY 60-2770 is an activator of soluble guanylate cyclase (sGC; EC50s = 592 and 573 nM for the α1β1 and α2β1 isoforms, respectively).1 It increases cGMP levels in, and inhibits the aggregation of, collagen- or thrombin-activated washed isolated human platelets, effects that can be potentiated by ODQ (Item No. 81410).2 BAY 60-2770 (10 µM) inhibits doxorubicin-induced decreases in the viability of, and increases in reactive oxygen species (ROS) levels in, H9c2 cardiomyocytes in an in vitro model of cardiotoxicity.3 It decreases pulmonary and systemic arterial pressure in a rat model of pulmonary hypertension induced by monocrotaline (Item No. 16666).4 BAY 60-2770 (1 mg/kg) reduces eosinophil infiltration into bronchoalveolar lavage fluid (BALF) and lung tissue in an ovalbumin-sensitized mouse model of allergic airway inflammation.5 It reverses obesity-induced increases in the frequency of voiding and non-voiding bladder contractions in mice fed a high-fat diet when administered at a dose of 1 mg/kg.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sömmer, A., Sandner, P., and Behrends, S. BAY 60-2770 activates two isoforms of nitric oxide sensitive guanylyl cyclase: Evidence for stable insertion of activator drugs. Biochem. Pharmacol. 147, 10-20 (2018).

    2. Mendes-Silverio, C.B., Leiria, L.O., Morganti, R.P., et al. Activation of haem-oxidized soluble guanylyl cyclase with BAY 60-2770 in human platelets lead to overstimulation of the cyclic GMP signaling pathway. PLoS One 7(11), e47223 (2012).

    3. Zhao, X.X., Cho, H., Lee, S., et al. BAY60-2770 attenuates doxorubicin-induced cardiotoxicity by decreased oxidative stress and enhanced autophagy. Chem. Biol. Interact. 328, 109190 (2020).

    4. Pankey, E.A., Bhartiya, M., Badejo, A.M., Jr., et al. Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase activator, BAY 60-2770, are not dependent on endogenous nitric oxide or reduced heme. Am. J. Physiol. Heart Circ. Physiol. 300(3), H792-H802 (2011).

    5. Baldissera, L., Jr., Squebola-Cola, D.M., Calixto, M.C., et al. The soluble guanylyl cyclase activator BAY 60-2770 inhibits murine allergic airways inflammation and human eosinophil chemotaxis. Pulm. Pharmacol. Ther. 41, 86-95 (2016).

    6. Leiria, L.O., Silva, F.H., Davel, A.P., et al. The soluble guanylyl cyclase activator BAY 60-2770 ameliorates overactive bladder in obese mice. J. Urol. 191(2), 539-547 (2014).