A LTB4 receptor antagonist
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Leukotriene B4 dimethyl amide

Item No. 20115

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-dimethyl-5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenamide
CAS Number
83024-92-4
Synonyms
  • LTB4 dimethyl amide
Molecular Formula
C22H37NO3
Formula Weight
363.5
Purity
≥97%
Formulation (Request formulation change)
A 100 µg/ml solution in methanol
Solubility(Learn about Variance in Solubility)
DMF: >50 mg/mlDMSO: >50 mg/mlEthanol: >50 mg/mlPBS pH 7.2: >1 mg/ml
λmax
270 nm
SMILES
CCCCC/C=C\C[C@@H](O)/C=C/C=C\C=C\[C@@H](O)CCCC(=O)N(C)C
InChi Code
InChI=1S/C22H37NO3/c1-4-5-6-7-8-11-15-20(24)16-12-9-10-13-17-21(25)18-14-19-22(26)23(2)3/h8-13,16-17,20-21,24-25H,4-7,14-15,18-19H2,1-3H3/b10-9+,11-8-,16-12+,17-13-/t20-,21-/m1/s1
InChi Key
BBJRTSLPWQUASB-UKODYPNASA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    25 µg

    $192

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    50 µg

    $361

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    100 µg

    $680

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    Product Description

    LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL.1,2,3 LTB4 dimethyl amide appears to be an antagonist of the LTB4 receptor on guinea pig lung membranes.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Showell, H.J., Otterness, I.G., Marfat, A., et al. Inhibition of leukotriene B4-induced neutrophil degranulation by leukotriene B4-dimethylamide. Biochem. Biophys. Res. Commun. 106, 741-747 (1982).

    2. Shimazaki, T., Kobayashi, Y., Sato, F., et al. Some newly synthesized leukotriene B4 analogs inhibit LTB4-induced lysozyme release from rat polymorphonuclear leukocytes. Prostaglandins 39, 459-467 (1990).

    3. Falcone, R.C., and Aharony, D. Modulation of ligand binding to leukotriene B4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents. J. Pharmacol. Exp. Ther. 255, 565-571 (1990).