A bioconjugation linker
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Maleimide-PEG2-AZD

Item No. 20129

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,5-dihydro-2,5-dioxo-N-[2-[2-[3-oxo-3-[[4-[3-oxo-3-(2-oxo-1-azetidinyl)propyl]phenyl]amino]propoxy]ethoxy]ethyl]-1H-pyrrole-1-propanamide
CAS Number
1037589-69-7
Synonyms
  • Mal-PEG2-AZD
Molecular Formula
C26H32N4O8
Formula Weight
528.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml
λmax
248 nm
SMILES
O=C(NCCOCCOCCC(NC1=CC=C(CCC(N2CCC2=O)=O)C=C1)=O)CCN3C(C=CC3=O)=O
InChi Code
InChI=1S/C26H32N4O8/c31-21(9-13-29-24(34)7-8-25(29)35)27-12-16-38-18-17-37-15-11-22(32)28-20-4-1-19(2-5-20)3-6-23(33)30-14-10-26(30)36/h1-2,4-5,7-8H,3,6,9-18H2,(H,27,31)(H,28,32)
InChi Key
BJDLYWUPKGDHCF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    Maleimide-PEG2-AZD is a heterobifunctional bioconjugation linker.1,2 It has been used in the development of protein- and peptidomimetic-antibody conjugates, including the FGF21 protein-antibody conjugate PF-05231023 and κ-opioid receptor (KOR) agonists, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roberts, L.R., Brady, K.D., Brown, A., et al. Kappa agonist CovX-Bodies. Bioorg. Med. Chem. Lett. 22(12), 4173-4178 (2012).

    2. Dirksen, A., Davis, K.A., Collins, J.T., et al. Process development of a FGF21 protein-antibody conjugate. Peptide Sci. 110(1), e23042 (2017).