A LTB4 receptor antagonist
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14,15-dehydro Leukotriene B4

Item No. 20150

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5S,12R-dihydroxy-6Z,8E,10E-eicosatrien-14-ynoic acid
CAS Number
114616-11-4
Synonyms
  • 14,15-dehydro LTB4
Molecular Formula
C20H30O4
Formula Weight
334.5
Purity
≥97%
Formulation
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: MiscibleDMSO: MiscibleEthanol: MisciblePBS (pH 7.2): >1 mg/ml
λmax
270 nm
SMILES
CCCCCCCC[C@@H](O)/C=C/C=C\C=C\[C@@H](O)CCCC(=O)O
InChi Code
InChI=1S/C20H30O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h7-8,10-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,14-10+,15-11-/t18-,19-/m1/s1
InChi Key
PRCVOEPTHWOJMX-CHHAPGPYSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    25 µg

    $152

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    50 µg

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    100 µg

    $541

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    Product Description

    14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM.1 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, S., Gustafson, E., Pang, L., et al. A novel hepatointestinal leukotriene B4 receptor. The Journal of Biological Chemisty 275(52), 40686-40694 (2000).

    2. Shimazaki, T., Kobayashi, Y., Sato, F., et al. Some newly synthesized leukotriene B4 analogs inhibit LTB4-induced lysozyme release from rat polymorphonuclear leukocytes. Prostaglandins 39, 459-467 (1990).