An activator of SIRT1, SIRT2, and SIRT3
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BML-278

Item No. 20209

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-dihydro-4-phenyl-1-(phenylmethyl)-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester
CAS Number
120533-76-8
Molecular Formula
C24H25NO4
Formula Weight
391.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12.5 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 3 mg/ml
λmax
226, 368 nm
SMILES
O=C(OCC)C1=CN(CC2=CC=CC=C2)C=C(C(OCC)=O)C1C3=CC=CC=C3
InChi Code
InChI=1S/C24H25NO4/c1-3-28-23(26)20-16-25(15-18-11-7-5-8-12-18)17-21(24(27)29-4-2)22(20)19-13-9-6-10-14-19/h5-14,16-17,22H,3-4,15H2,1-2H3
InChi Key
JOHFECBOWRGWJZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $86

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    10 mg

    $153

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    25 mg

    $336

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    Product Description

    BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 µM.1 It less potently activates SIRT2 and SIRT3 (EC150s = 25 and 50 µM, respectively).1 BML-278 induces hypoacetylation on α-tubulin in U937 cells that are pretreated with SAHA (Item No. 10009929), a histone deacetylase inhibitor. It arrests cell cycling at the G1/S phase, reduces senescence in primary human mesenchymal cells, and significantly increases mitochondrial density in murine C2C12 myoblasts.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mai, A., Valente, S., Meade, S., et al. Study of 1,4-dihydropyridine structural scaffold: Discovery of novel sirtuin activators and inhibitors. J. Med. Chem. 52(17), 5496-5504 (2009).