A selective PKC inhibitor
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NPC-15437 (hydrochloride)

Item No. 20212

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-2,6-diamino-N-[[1-(1-oxotridecyl)-2-piperidinyl]methyl]-hexanamide, dihydrochloride
CAS Number
141774-20-1
Molecular Formula
C25H50N4O2 • 2HCl
Formula Weight
511.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O=C(CCCCCCCCCCCC)N1CCCCC1CNC([C@@H](N)CCCCN)=O.Cl.Cl
InChi Code
InChI=1S/C25H50N4O2.2ClH/c1-2-3-4-5-6-7-8-9-10-11-18-24(30)29-20-15-13-16-22(29)21-28-25(31)23(27)17-12-14-19-26;;/h22-23H,2-21,26-27H2,1H3,(H,28,31);2*1H/t22?,23-;;/m0../s1
InChi Key
RISSBZWRJRRXTD-OLBPYZPGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $42

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    1 mg

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    5 mg

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    Product Description

    NPC-15437 is a selective protein kinase C (PKC) inhibitor (IC50 = 19 µM).1 It competitively inhibits phorbol ester- (Ki = 5 µM) and phosphatidylserine-induced (Ki = 12 µM) PKC activity but does not affect the activity of cAMP-dependent or Ca2+/calmodulin-dependent protein kinases. PKC signaling is involved in learning and memory, and when NPC-15437 was administered after Y maze training (0.1-10 mg/kg i.p.), it led to memory retention deficits in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sullivan, J.P., Connor, J.R., Shearer, B.G., et al. 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain. Mol. Pharmacol. 41(1), 38-44 (1992).

    2. Mathis, C., Lehmann, J., and Ungerer, A. The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice. Eur. J. Pharmacol. 220(1), 107-110 (1992).