An inhibitor of RSKs
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BRD7389

Item No. 20214

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(2-phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
CAS Number
376382-11-5
Molecular Formula
C24H18N2O2
Formula Weight
366.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mLDMF:PBS (pH 7.2)(1:3): 0.25 mg/mLDMSO: 12.5 mg/mLEthanol: slightly soluble
λmax
227, 239, 343, 444 nm
SMILES
O=C(C1=C2C(N3)=CC=C1)C4=CC=CC=C4C2=C(NCCC5=CC=CC=C5)C3=O
InChi Code
InChI=1S/C24H18N2O2/c27-23-17-10-5-4-9-16(17)21-20-18(23)11-6-12-19(20)26-24(28)22(21)25-14-13-15-7-2-1-3-8-15/h1-12,25H,13-14H2,(H,26,28)
InChi Key
XASCINRGTHLHGM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

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    10 mg

    $194

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    BRD7389 is an inhibitor of ribosomal S6 kinases (RSKs; IC50s = 1.5, 2.4, and 1.2 μM for RSK1, RSK2, and RSK3, respectively).1 Through this action, BRD7389 causes mouse αTC1 pancreatic α cells to adopt several morphological and gene expression features of β cells, including increased insulin expression.1 BRD7389 also enhances glucose-stimulated insulin and glucagon secretion by pancreatic islet cells isolated from human donors with a low body mass index.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fomina-Yadlin, D., Kubicek, S., Walpita, D., et al. Small-molecule inducers of insulin expression in pancreatic α-cells. Proc. Natl. Acad. Sci. USA 107(34), 15099-15104 (2010).