A JNK3 inhibitor
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SR 3576

Item No. 20215

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[4-[[[(3-methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide
CAS Number
1164153-22-3
Molecular Formula
C27H27N5O5
Formula Weight
501.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 40 mg/ml
SMILES
CC1=CC=CC(NC(NC2=CN(C3=CC=CC(C(NC4=CC(OC)=C(OC)C(OC)=C4)=O)=C3)N=C2)=O)=C1
InChi Code
InChI=1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34)
InChi Key
MTFAYLZZDJGFGV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    Product Description

    SR 3576 is a JNK3 inhibitor (IC50 = 7 nM).1 It is selective for JNK3 over JNK1 and p38 MAP kinase (IC50s = 0.17 and >20 µM, respectively). It inhibits c-Jun phosphorylation in INS-1 cells (IC50 = 1.3 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kamenecka, T., Habel, J., Duckett, D., et al. Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. The Journal of Biological Chemisty 284(19), 12853-12861 (2009).