A potent and selective α1-AR antagonist
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Terazosin (hydrochloride)

Item No. 20216

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)-methanone, monohydrochloride
CAS Number
63074-08-8
Molecular Formula
C19H25N5O4 • HCl
Formula Weight
423.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.1 mg/ml
λmax
214, 247 nm
SMILES
COC1=C(OC)C=C(C(N)=NC(N2CCN(C(C3CCCO3)=O)CC2)=N4)C4=C1.Cl
InChi Code
InChI=1S/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H
InChi Key
IWSWDOUXSCRCKW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $121

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    250 mg

    $240

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    500 mg

    $388

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    1 g

    $713

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    Product Description

    Terazosin is a potent and selective α1-adrenergic receptor (α1-AR) antagonist (Kis = 3.28, 0.68, and 1.09 for α1A-, α1B- and α1D-ARs, respectively).1 It is selective for α1- over α2-AR subtypes (Kis = 1,510, 7.71, and 78.2 nM for A2a-, A2b-, and A2c-ARs, respectively). Terazosin (0.1-30 mg/kg) decreases blood pressure in spontaneously hypertensive rats.2 It also decreases blood pressure in anesthetized dogs. Formulations containing terazosin are used to treat hypertension and benign prostatic hyperplasia.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hancock, A.A., Buckner, S.A., Ireland, L.M., et al. Actions of terazosin and its enantiomers at subtypes of α- and α2-adrenoceptors in vitro. J. Recept. Signal Transduct. Res. 15(7-8), 863-885 (1995).

    2. Kyncl, J.J. Pharmacology of terazosin. Am. J. Med. 80(5B), 12-19 (1986).

    3. Cohen, J.D. Long-term efficacy and safety of terazosin alone and in combination with other antihypertensive agents. Am. Heart J. 122(3 Pt 2), 919-925 (1991).

    4. Lepor, H., Williford, W.O., Barry, M.J., et al. The efficacy of terazosin, finasteride, or both in benign prostatic hyperplasia. N. Engl. J. Med. 335(8), 533-539 (1996).