A selective CB2 partial agonist
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GW 405833

Item No. 20219

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2,3-dichlorophenyl)[5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indol-1-yl]-methanone
CAS Number
180002-83-9
Synonyms
  • L-768,242
Molecular Formula
C23H24Cl2N2O3
Formula Weight
447.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 5 mg/mlEthanol: 0.3 mg/ml
λmax
264, 315 nm
SMILES
COC1=CC=C(N(C(C2=C(Cl)C(Cl)=CC=C2)=O)C(C)=C3CCN4CCOCC4)C3=C1
InChi Code
InChI=1S/C23H24Cl2N2O3/c1-15-17(8-9-26-10-12-30-13-11-26)19-14-16(29-2)6-7-21(19)27(15)23(28)18-4-3-5-20(24)22(18)25/h3-7,14H,8-13H2,1-2H3
InChi Key
FSFZRNZSZYDVLI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $38

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    5 mg

    $94

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    10 mg

    $129

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    25 mg

    $274

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    Product Description

    GW 405833 is a partial agonist of the cannabinoid CB2 receptor (EC50 = 0.65 nM).1 It is selective for CB2, binding with a Ki value of 14 nM compared to that of CB1 with a Ki value of 2.04 µM.1 GW 405833 demonstrates anti-inflammatory and antihyperalgesic properties in animal models of inflammation and pain.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guindon, J., and Hohmann, A.G. Cannabinoid CB2 receptors: A therapeutic target for the treatment of inflammatory and neuropathic pain. Br. J. Pharmacol. 153(2), 319-334 (2008).