A selective adenosine A2A receptor antagonist
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Vipadenant

Item No. 20239

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(4-amino-3-methylphenyl)methyl]-7-(2-furanyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine
CAS Number
442908-10-3
Synonyms
  • BIIB-014
Molecular Formula
C16H15N7O
Formula Weight
321.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 43 mg/mL
λmax
231, 301, 349 nm
SMILES
NC1=NC(C2=CC=CO2)=C3C(N(CC4=CC=C(N)C(C)=C4)N=N3)=N1
InChi Code
InChI=1S/C16H15N7O/c1-9-7-10(4-5-11(9)17)8-23-15-14(21-22-23)13(19-16(18)20-15)12-3-2-6-24-12/h2-7H,8,17H2,1H3,(H2,18,19,20)
InChi Key
HQSBCDPYXDGTCL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $75

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    1 mg

    $134

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    5 mg

    $516

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    Product Description

    Vipadenant is a selective adenosine 2A (A2A) receptor antagonist with Ki values of 1.3, 68, 63, and 1,005 nM for A2A, A1, A2B, and A3 receptors, respectively, in a radioligand binding assay.1 It acts as a functional antagonist of human recombinant A2A (KA = 0.58 nM) in a calcium mobilization-based FLIPR assay. Vipadenant also reverses haloperidol-induced hypolocomotion in mice and rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gillespie, R.J., Bamford, S.J., Botting, R., et al. Antagonists of the human A2A adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines. J. Med. Chem. 52(1), 33-47 (2009).