An NSAID and a prodrug form of 6-methoxy naphthalene acetic acid
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Nabumetone

Item No. 20251

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(6-methoxy-2-naphthalenyl)-2-butanone
CAS Number
42924-53-8
Synonyms
  • BRL 14777
Molecular Formula
C15H16O2
Formula Weight
228.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.09 mg/mlEthanol: 20 mg/ml
λmax
230 nm
SMILES
COC1=CC=C2C(C=CC(CCC(C)=O)=C2)=C1
InChi Code
InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3
InChi Key
BLXXJMDCKKHMKV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    5 g

    $115

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    10 g

    $156

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    25 g

    $278

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    Product Description

    Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 6-methoxy naphthalene acetic acid (Item No. 70620).1 Nabumetone (5-45 mg/kg) reduces carrageenan-induced edema in rats, as well as UV-induced erythema in guinea pigs (ED50 = 11 mg/kg).2 It reduces phenyl-p-quinone-induced writhing in mice (ED50 = 152 mg/kg). Nabumetone (50, 100, and 200 mg/kg) reduces endotoxin-induced pyresis in rabbits.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cryer, B., and Feldman, M. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs. Am. J. Med. 104(5), 413-421 (1998).

    2. Boyle, E.A., Freeman, P.C., Mangan, F.R., et al. Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agent. J. Pharm. Pharmacol. 34(9), 562-569 (1982).