A non-selective COX inhibitor
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6-methoxy Naphthalene Acetic Acid

Item No. 70620

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-methoxy-2-naphthaleneacetic acid
CAS Number
23981-47-7
Synonyms
  • 6-MNA
Molecular Formula
C13H12O3
Formula Weight
216.2
Purity
≥99%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/ml (from (+/-)-NaproxenDMSO: 24 mg/ml (from (+/-)-NaproxenEthanol: 55 mg/ml (from (+/-)-NaproxenPBS pH 7.2: 3 mg/ml (from (+/-)-Naproxen)
λmax
231 nm
SMILES
COC1=CC(C=CC(CC(O)=O)=C2)=C2C=C1
InChi Code
InChI=1S/C13H12O3/c1-16-12-5-4-10-6-9(7-13(14)15)2-3-11(10)8-12/h2-6,8H,7H2,1H3,(H,14,15)
InChi Key
PHJFLPMVEFKEPL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

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    50 mg

    $153

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    100 mg

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    Product Description

    6-MNA is a competitive, non-selective COX inhibitor.1,2,3 The Ki values for ovine COX-1 and -2 are 21 and 19 µM, respectively.2 The IC50 values are 70 and 20 µM for human recombinant COX-1 and -2, respectively.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys. Acta 1209(1), 130-139 (1994).

    2. Johnson, J.L., Wimsatt, J., Buckel, S.D., et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch. Biochem. Biophys. 324(1), 26-34 (1995).

    3. Laneuville, O., Breuer, D.K., DeWitt, D.L., et al. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J. Pharmacol. Exp. Ther. 271(2), 927-934 (1994).