An FXR receptor antagonist
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Tauro-α-muricholic Acid (sodium salt)

Item No. 20288

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(3α,5β,6β,7α)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt
CAS Number
2260905-08-4
Synonyms
  • Tauro-α-muricholate
  • TαMCA
Molecular Formula
C26H44NO7S • Na
Formula Weight
537.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mLDMSO: 10 mg/mLDMSO:PBS(pH 7.2) (1:4): 0.2 mg/mLEthanol: 1 mg/mL
SMILES
C[C@H](CCC(NCCS([O-])(=O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)[C@@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na+]
InChi Code
InChI=1S/C26H45NO7S.Na/c1-15(4-7-21(29)27-12-13-35(32,33)34)17-5-6-18-22-19(9-11-25(17,18)2)26(3)10-8-16(28)14-20(26)23(30)24(22)31;/h15-20,22-24,28,30-31H,4-14H2,1-3H3,(H,27,29)(H,32,33,34);/q;+1/p-1/t15-,16-,17-,18+,19+,20+,22+,23+,24+,25-,26-;/m1./s1
InChi Key
NYXROOLWUZIWRB-BAMGEBLESA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $193

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    Product Description

    Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 µM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid (Item No. 20291).1 TαMCA is common in rodents but has also been found in small amounts in human serum.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sayin, S.I., Wahlström, A., Felin, J., et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 17(2), 225-235 (2013).

    2. García-Cañaveras, J.C., Donato, M.T., Castell, J.V., et al. Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method. J. Lipid Res. 53(10), 2231-2241 (2012).

    Product Citations

    Wei, W., Lyu, X., Markhard, A.L., et al. PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity. Nature 633(8028), 182-188 (2023).